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PostDoc Research @UMMC
PostDoc Research @UMMC
Macrophage Metabolism in Post-MI Cardiac Remodeling
Macrophage Metabolism in Post-MI Cardiac Remodeling
Our lab investigates how macrophage metabolism influences heart repair after myocardial infarction (MI), focusing on the balance between pro-inflammatory M1 and reparative M2 macrophages. Macrophages are central to clearing dead tissue, resolving inflammation, and guiding scar formation. Metabolic reprogramming—particularly in lactate and ketone pathways—may determine whether these cells promote damage or repair. We use a combination of in vivo and in vitro approaches:
Our lab investigates how macrophage metabolism influences heart repair after myocardial infarction (MI), focusing on the balance between pro-inflammatory M1 and reparative M2 macrophages. Macrophages are central to clearing dead tissue, resolving inflammation, and guiding scar formation. Metabolic reprogramming—particularly in lactate and ketone pathways—may determine whether these cells promote damage or repair. We use a combination of in vivo and in vitro approaches:
-Mouse Myocardia-infraction models via coronary artery ligation.
-Mouse Myocardia-infraction models via coronary artery ligation.
-Flow Cytometry-to analyze the macrophage population
-Flow Cytometry-to analyze the macrophage population
-Bone marrow–derived macrophage cultures.
-Bone marrow–derived macrophage cultures.
-Echocardiogram- to observe the impact of the MI
-Echocardiogram- to observe the impact of the MI
-Seahorse extracellular flux analysis to measure metabolism.
-Seahorse extracellular flux analysis to measure metabolism.
-RNA-seq and quantitative RT-PCR to define transcriptional programs.
-RNA-seq and quantitative RT-PCR to define transcriptional programs.
-Immunohistochemistry to visualize macrophage localization.
-Immunohistochemistry to visualize macrophage localization.
Our goal is to uncover how shifting macrophage metabolism toward lactate and ketone utilization can resolve inflammation, enhance scar quality, and preserve heart function. This work may identify new metabolism-targeted therapies to improve recovery after MI, particularly for patients with T2DM who face higher risks of poor outcomes.
Our goal is to uncover how shifting macrophage metabolism toward lactate and ketone utilization can resolve inflammation, enhance scar quality, and preserve heart function. This work may identify new metabolism-targeted therapies to improve recovery after MI, particularly for patients with T2DM who face higher risks of poor outcomes.
Postdoc Research @Auburn University
Postdoc Research @Auburn University
Single-nucleus/cell RNAseq, Long-read RNA sequencing, and Fluorescence Microscopy to determine gene regulation in Drosophila brain tissue.
Single-nucleus/cell RNAseq, Long-read RNA sequencing, and Fluorescence Microscopy to determine gene regulation in Drosophila brain tissue.
PhD Research
PhD Research
Sex Differences in the Drosophila Immune Response: Evolution & Molecular Mechanisms.
Sex Differences in the Drosophila Immune Response: Evolution & Molecular Mechanisms.
MS Research
MS Research
Stress modulation and determination of the stress-related immune response of tilapia in the presence of mitogen and nutraceutical elderberry extract.
Stress modulation and determination of the stress-related immune response of tilapia in the presence of mitogen and nutraceutical elderberry extract.
Research Institution
Research Institution
Gov. Institutional Research:
Gov. Institutional Research:
- Jute Genome Seq Project: Corchorus olitorius and C. capsularis (2011-2014)
- Jute Genome Seq Project: Corchorus olitorius and C. capsularis (2011-2014)
- Macrophomina Genome Seq Project: Macrophomina phaseolina (2011-2014)
- Macrophomina Genome Seq Project: Macrophomina phaseolina (2011-2014)
Advisor: Maqsudul Alam, Professor, Dept. of Microbiology, University of Hawaii & Principal Investigator, Bangladesh Jute Research Institute, Dhaka, BD.
Advisor: Maqsudul Alam, Professor, Dept. of Microbiology, University of Hawaii & Principal Investigator, Bangladesh Jute Research Institute, Dhaka, BD.
MS Research
MS Research
Cloning and transformation of Glyoxalase I and Glyoxalase II genes into rice (Oryza sativa) to increase salt tolerance.
Cloning and transformation of Glyoxalase I and Glyoxalase II genes into rice (Oryza sativa) to increase salt tolerance.
Advisor: Dr. Zeba Seraj, Professor, Dept of Biochemistry and Molecular Biology, University of Dhaka, BD
Advisor: Dr. Zeba Seraj, Professor, Dept of Biochemistry and Molecular Biology, University of Dhaka, BD
UG Honors Research
UG Honors Research
Rapid and clonal propagation of the medicinal plant Adhatoda vasica.
Rapid and clonal propagation of the medicinal plant Adhatoda vasica.
Advisor: Dr. Selim Khan, Principal Scientific Officer (PSO), Bangladesh Council of Scientific & Industrial Research.
Advisor: Dr. Selim Khan, Principal Scientific Officer (PSO), Bangladesh Council of Scientific & Industrial Research.
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